New ring C-seco limonoids from Brazilian Melia azedarach and their cytotoxic activity

  • J Nat Prod. 2004 Sep;67(9):1544-7. doi: 10.1021/np040077r.
Honglei Zhou  1 ,  Atsuko Hamazaki ,  Jose Domingos Fontana ,  Hironobu Takahashi ,  Tomoyuki Esumi ,  Carolina Bueno Wandscheer ,  Hiroaki Tsujimoto ,  Yoshiyasu Fukuyama
Affiliations
  • 1. Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
PMID: 15387656 DOI: 10.1021/np040077r
Abstract

A methanol extract of the ripe fruits of Melia azedarach collected in Curitiba, Parana, Brazil, afforded seven new ring C-seco limonoids (1-7) together with three known limonoids (8-10). The structures of the new compounds were elucidated by NMR and MS analysis and comparison of spectral data with those of previously known compounds. Compounds 4 and 5 exhibited significant inhibitory activity against HeLa S3 Cancer cells, whereas 1, 2, 3, and 8 showed weak cytotoxicity.