Cytotoxic steroidal saponins from Polygonatum zanlanscianense

  • J Nat Prod. 2004 Dec;67(12):1992-5. doi: 10.1021/np049897u.
Jian-Ming Jin  1 ,  Ying-Jun Zhang ,  Hai-Zhou Li ,  Chong-Ren Yang
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 15620239 DOI: 10.1021/np049897u
Abstract

Four new steroidal saponins, polygonatosides A-D (1-4), were isolated from the rhizomes of Polygonatum zanlanscianense, together with six known spirostanols (5-10) and a known megastigmane glycoside (11). Their structures were elucidated on the basis of spectroscopic analysis and the results of acidic and enzymatic hydrolysis. The cytotoxic activities of 1-11 against HeLa cells are described.