Antibacterial constituents from the berries of Piper nigrum

  • Phytomedicine. 2004 Nov;11(7-8):697-700. doi: 10.1016/j.phymed.2003.04.004.
S Venkat Reddy  1 ,  Pullela V Srinivas ,  B Praveen ,  K Hara Kishore ,  B China Raju ,  U Suryanarayana Murthy ,  J Madhusudana Rao
Affiliations
  • 1. Natural Product Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
PMID: 15636188 DOI: 10.1016/j.phymed.2003.04.004
Abstract

Piper nigrum finds an extensive application in Antibacterial preparations belonging to Ayurvedic system of medicine. A bioguided extraction and fractionation of the petroleum ether extract of the berries of P. nigrum afforded 2E, 4E, 8Z-N-isobutyleicosatrienamide (1), pellitorine (2), trachyone (3), pergumidiene (4) and isopiperolein B (5). Pergumidiene and trachyone are isolated for the first time from P. nigrum. All the isolated compounds were active against Bacillus subtilis, Bacillus sphaericus, and Staphylococcus aureus amongst Gram + ve bacteria, and Klebsiella aerogenes and Chromobacterium violaceum among Gram -ve Bacterial strains.

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