Cytotoxic hydroxylated triterpene alcohol ferulates from rice bran

  • J Nat Prod. 2005 Jan;68(1):94-7. doi: 10.1021/np049889d.
Hong-Feng Luo  1 ,  Qinglin Li ,  Shanggong Yu ,  Thomas M Badger ,  Nianbai Fang
Affiliations
  • 1. Arkansas Children's Nutrition Center, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA.
PMID: 15679326 DOI: 10.1021/np049889d
Abstract

Three hydroxylated triterpene alcohol ferulates, (24S)-cycloart-25-ene-3 beta,24-diol-3 beta-trans-ferulate (1), (24R)-cycloart-25-ene-3 beta,24-diol-3 beta-trans-ferulate (2), and cycloart-23Z-ene-3 beta,25-diol-3 beta-trans-ferulate (3), along with known compounds cycloartenol trans-ferulate (4) and 24-methylenecycloartanol trans-ferulate (5) were isolated from rice bran. Their structures were elucidated by means of chemical and spectroscopic analysis. Compounds 2-5 showed moderate cytotoxicity against MCF-7 cells.