The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease

  • Naunyn Schmiedebergs Arch Pharmacol. 2005 Apr;371(4):295-306. doi: 10.1007/s00210-005-1021-2.
Monique van Abel  1 ,  Joost G J Hoenderop ,  René J M Bindels
Affiliations
  • 1. Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
PMID: 15747113 DOI: 10.1007/s00210-005-1021-2
Abstract

The epithelial CA(2+) channels TRPV5 and TRPV6 represent a new family of CA(2+) channels that belongs to the superfamily of transient receptor potential channels. TRPV5 and TRPV6 constitute the apical CA(2+) entry mechanism in active CA(2+) transport in kidney and intestine. The central role of TRPV5 and TRPV6 in active CA(2+) (re)absorption makes it a prime target for regulation to maintain CA(2+) balance. This review covers the hormonal regulation, interaction with accessory proteins and (patho)physiological implications of these epithelial CA(2+) channels.