Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica

  • J Nat Prod. 2005 Mar;68(3):427-9. doi: 10.1021/np049662i.
Xiao Y Wei  1 ,  Chung Y Leung ,  Chris K C Wong ,  Xiao L Shen ,  Ricky N S Wong ,  Zong W Cai ,  Nai K Mak
Affiliations
  • 1. Department of Biology, Hong Kong Baptist University, Kowloog Tong, Hong Kong, People's Republic of China.
PMID: 15787451 DOI: 10.1021/np049662i
Abstract

A new indigoid derivative, bisindigotin (1), with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-antagonistic activity was isolated from the ethanol extract of the Chinese medicinal herb Isatis indigotica. Its structure was determined by spectroscopic methods. In the human HepG2 hepatoma cell model, 1 (50 nM to 2 microM) was found to dose-dependently inhibit TCDD-induced ethoxyresorufin O-deethylase (EROD) activity.