Anti-HIV protease activity from rosa family plant extracts and rosamultin from Rosa rugosa

  • J Med Food. 2005 Spring;8(1):107-9. doi: 10.1089/jmf.2005.8.107.
Jong Cheol Park  1 ,  Sang Chul Kim ,  Myeong Rak Choi ,  Sang Ho Song ,  Eun Jeong Yoo ,  Sung Hwan Kim ,  Hirotsugu Miyashiro ,  Masao Hattori
Affiliations
  • 1. Department of Oriental Medicine Resources and Research Institute of Korean Oriental Medicine, Sunchon National University, Suncheon, Jeonnam, Republic of Korea. [email protected]
PMID: 15857219 DOI: 10.1089/jmf.2005.8.107
Abstract

To identify substances with anti-human immunodeficiency virus (HIV) activity from plant sources, 12 extracts of Rosa family Plants were screened for their inhibitory effects against HIV-1 protease. Of the extracts tested, the strongest inhibitory effects were observed in the root of Rosa rugosa and the leaves of Prunus sargentii, at a concentration of 100 microg/mL. Rosamultin isolated from the root of R. rugosa inhibited HIV-1 protease by 53% at a concentration of 100 microM.

Products