1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists

  • Bioorg Med Chem Lett. 2005 Jul 15;15(14):3430-3. doi: 10.1016/j.bmcl.2005.05.012.
Raman K Bakshi  1 ,  Qingmei Hong ,  J T Olson ,  Zhixiong Ye ,  Iyassue K Sebhat ,  David H Weinberg ,  Tanya MacNeil ,  Rubana N Kalyani ,  Rui Tang ,  William J Martin ,  Alison Strack ,  Erin McGowan ,  Constantin Tamvakopoulos ,  Randy R Miller ,  Ralph A Stearns ,  Wei Tang ,  D Euan Maclntyre ,  Lex H T van der Ploeg ,  Arthur A Patchett ,  Ravi P Nargund
Affiliations
  • 1. Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. [email protected]
PMID: 15951175 DOI: 10.1016/j.bmcl.2005.05.012
Abstract

The discovery of 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid analogs as potent human melanocortin-4 selective agonists is described.