In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma

  • Planta Med. 2005 Aug;71(8):778-80. doi: 10.1055/s-2005-871213.
Kyung Ah Koo  1 ,  Sang Hyun Sung ,  Jong Hee Park ,  Seung Hyun Kim ,  Ki Yong Lee ,  Young Choong Kim
Affiliations
  • 1. College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea.
PMID: 16142646 DOI: 10.1055/s-2005-871213
Abstract

Ten phenylethanoid glycosides, forsythoside B, acteoside, 2'-acetylacteoside, poliumoside, brandioside, echinacoside, isoacteoside, cistanoside H and E-tubuloside E as well as a new compound, Z-tubuloside E, were isolated from the n-BuOH fraction of Callicarpa dichotoma Raeuschel (Verbenaceae) by bioactivity-guided fractionation using glutamate-injured primary cultures of rat cortical cells as a screening system. These phenylethanoid glycosides significantly attenuated glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 microM.

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