Homocysteine and schizophrenia: from prenatal to adult life

  • Prog Neuropsychopharmacol Biol Psychiatry. 2005 Sep;29(7):1175-80. doi: 10.1016/j.pnpbp.2005.06.028.
Alan S Brown  1 ,  Ezra S Susser
Affiliations
  • 1. College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA. [email protected]
PMID: 16143442 DOI: 10.1016/j.pnpbp.2005.06.028
Abstract

Homocysteine is becoming increasingly recognized as an important substance in the pathogenesis and pathophysiology of schizophrenia. In this review, we first present background information supporting a role for homocysteine in schizophrenia. We then discuss our work on the role of hyperhomocystinemia during adulthood and risk of schizophrenia, and present preliminary evidence on a potential relationship between prenatal homocysteine and schizophrenia. Finally, we discuss the implications of these findings for future work on nutritional etiologies of schizophrenia.

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