Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents

  • Bioorg Med Chem Lett. 2005 Dec 1;15(23):5284-7. doi: 10.1016/j.bmcl.2005.08.046.
Wen-Long Wang  1 ,  De-Yong Yao ,  Min Gu ,  Min-Zhi Fan ,  Jing-Ya Li ,  Ya-Cheng Xing ,  Fa-Jun Nan
Affiliations
  • 1. Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai 201203, China.
PMID: 16183283 DOI: 10.1016/j.bmcl.2005.08.046
Abstract

A series of novel 4,2-bisheterocycle tandem derivatives consisting of a methyloxazole and thiazole subunit were synthesized. Many compounds were found to inhibit human influenza A virus. Several analogues exhibited moderate biological activity and could serve as leads for further optimizations for antivirus research.