Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors

  • Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. doi: 10.1016/j.bmcl.2005.08.059.
Manik Pullagurla  1 ,  Uma Siripurapu ,  Renata Kolanos ,  Mikhail L Bondarev ,  Małgorzata Dukat ,  V Setola ,  B L Roth ,  Richard A Glennon
Affiliations
  • 1. Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.
PMID: 16183286 DOI: 10.1016/j.bmcl.2005.08.059
Abstract

An examination of several amine-substituted analogs of N(1)-benzenesulfonylindoles reveals that although they bind at human 5-HT(6) serotonin receptors with high affinity, they are likely to bind in a dissimilar manner.

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