4-benzyl-3-phenyl-5H-furan-2-one, a vasodilator isolated from Malbranchea filamentosa IFM 41300

  • Phytochemistry. 2005 Dec;66(23):2776-9. doi: 10.1016/j.phytochem.2005.08.014.
Tomoo Hosoe  1 ,  Toru Iizuka ,  Shin-ichirou Komai ,  Daigo Wakana ,  Takeshi Itabashi ,  Koohei Nozawa ,  Kazutaka Fukushima ,  Ken-ichi Kawai
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Tokyo 142-8501, Japan. [email protected]
PMID: 16213536 DOI: 10.1016/j.phytochem.2005.08.014
Abstract

Screening of Malbranchea filamentosa IFM 41300 for bioactive compounds led to the identification of 4-benzyl-3-phenyl-5H-furan-2-one (1) as a vasodilator and erythroglaucin (2). The structure of 1 was established on the basis of spectroscopic and chemical investigations. Compound 1 inhibited Ca2+-induced vasocintraction in aortic rings pretreated with high K+ (60mM) or norepinephrine. Finally, compound 1 did not exhibit activity against human pathogenic Microorganisms.

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