N-Sulfonyl hydroxamate derivatives as inhibitors of class II fructose-1,6-diphosphate aldolase

  • Bioorg Med Chem Lett. 2005 Dec 15;15(24):5375-7. doi: 10.1016/j.bmcl.2005.09.006.
Sabine Gavalda  1 ,  Rémi Braga ,  Chantal Dax ,  Alain Vigroux ,  Casimir Blonski
Affiliations
  • 1. Laboratoire de Synthèse et de Physico-Chimie de Molécules d'intérêt Biologique, Groupe de Chimie Organique Biologique, UMR 5068, Université Paul Sabatier, Bât IIR1, 118 route de Narbonne, 31062 Toulouse Cedex 4, France.
PMID: 16236509 DOI: 10.1016/j.bmcl.2005.09.006
Abstract

Dihydroxyacetone-phosphate and phosphonate derivatives were synthesized bearing a N-sulfonyl hydroxamate moiety. The phosphate derivatives represent competitive inhibitors for the class II-FBP aldolase catalyzed reaction, while the phosphonate isosteres are comparatively weaker inhibitors.

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