Labdane diterpenes from Aster spathulifolius and their cytotoxic effects on human cancer cell lines

  • J Nat Prod. 2005 Oct;68(10):1471-4. doi: 10.1021/np058044e.
Sung Ok Lee  1 ,  Sang Zin Choi ,  Sang Un Choi ,  Kang Choon Lee ,  Young Won Chin ,  Jinwoong Kim ,  Young Choong Kim ,  Kang Ro Lee
Affiliations
  • 1. College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea, Korea Research Institute of Chemical Technology, Taejeon 305-600, Korea.
PMID: 16252909 DOI: 10.1021/np058044e
Abstract

Three new labdane diterpenes (1-3), together with eight known Diterpenoids, were isolated from a methanol extract of the aerial parts of Aster spathulifolius. The structures of 1-3 were determined as (13R)-labda-7,14-diene 13-O-beta-d-(4'-O-acetyl)fucopyranoside (1), (13R)-labda-7,14-diene 13-O-beta-d-(3'-O-acetyl)fucopyranoside (2), and (13R)-labda-14(15)-en-8,13-diol 13-O-beta-d-fucopyranoside (3), on the basis of spectroscopic and chemical methods. Compounds 1, 2, and four of the known compounds exhibited generally nonspecific cytotoxicity against human A549, SK-OV-3, SK-MEL-2, XF498, and HCT15 tumor cells.