Isolation of new rotenoids from Boerhaavia diffusa and evaluation of their effect on intestinal motility

  • Planta Med. 2005 Oct;71(10):928-32. doi: 10.1055/s-2005-871282.
Francesca Borrelli  1 ,  Natasa Milic ,  Valeria Ascione ,  Raffaele Capasso ,  Angelo A Izzo ,  Francesco Capasso ,  Francesca Petrucci ,  Roberta Valente ,  Ernesto Fattorusso ,  Orazio Taglialatela-Scafati
Affiliations
  • 1. Dipartimento di Farmacologia Sperimentale, Università di Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy. [email protected]
PMID: 16254824 DOI: 10.1055/s-2005-871282
Abstract

A bioassay-guided separation of a methanolic extract obtained from the roots of Boerhaavia diffusa L. (Nyctaginaceae) allowed us to isolate five compounds belonging to the class of rotenoids: the known boeravinone D ( 1), boeravinone E ( 2), compound 5 and two novel compounds that we have named boeravinone G ( 3) and boeravinone H ( 4). The structures of the new molecules have been determined on the basis of their HR-EI-MS, (1)H- and (13)C-NMR and 2D-NMR (HMQC, HMBC) data. All the isolated rotenoids have been evaluated for their effect on intestinal motility in vitro. Three of them (boeravinone G, boeravinone E and compound 5) exhibited spasmolytic activity. Preliminary structure-activity relationships have been established highlighting the effect of substitutions on rings B and D.

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