Privileged structure-based quinazolinone natural product-templated libraries: identification of novel tubulin polymerization inhibitors
- Bioorg Med Chem Lett. 2006 Feb;16(3):686-90. doi: 10.1016/j.bmcl.2005.10.022.
Affiliations
- 1. ArQule, Inc., 19 Presidential Way, Woburn, MA 01801, USA. [email protected]
PMID: 16257201
DOI: 10.1016/j.bmcl.2005.10.022
Abstract
A focused quinazolinone natural product-templated library was designed and synthesized. Compounds from this privileged structure-based library were identified as antimitotic agents acting through destabilization of tubulin polymerization. The results suggested that 2 could be a privileged substructure.