ent-Labdane diterpenoids from Andrographis paniculata

  • J Nat Prod. 2006 Mar;69(3):319-22. doi: 10.1021/np050160u.
Yun-Heng Shen  1 ,  Rong-Tao Li ,  Wei-Lie Xiao ,  Gang Xu ,  Zhong-Wen Lin ,  Qin-Shi Zhao ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, People's Republic of China.
PMID: 16562826 DOI: 10.1021/np050160u
Abstract

Six new ent-labdane Diterpenoids, 3-O-beta-D-glucopyranosyl-14,19-dideoxyandrographolide (1), 14-deoxy-17-hydroxyandrographolide (2), 19-O-[beta-D-apiofuranosyl(1-->2)-beta-D-glucopyranoyl]-3,14-dideoxyandrographolide (3), 3-O-beta-d-glucopyranosylandrographolide (4), 12S-hydroxyandrographolide (5), and andrographatoside (6), together with 17 known analogues, were isolated from the aerial parts of Andrographis paniculata. The structures of 1-6 were determined by spectroscopic data analysis. All compounds isolated were evaluated for their inhibitory activity against several Bacterial and Fungal strains.

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