Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands

  • Bioorg Med Chem Lett. 2006 Jun 15;16(12):3213-8. doi: 10.1016/j.bmcl.2006.03.075.
Masahiko Kainuma  1 ,  Jun-ichi Kasuga ,  Shinnosuke Hosoda ,  Ken-ichi Wakabayashi ,  Aya Tanatani ,  Kazuo Nagasawa ,  Hiroyuki Miyachi ,  Makoto Makishima ,  Yuichi Hashimoto
Affiliations
  • 1. Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
PMID: 16617018 DOI: 10.1016/j.bmcl.2006.03.075
Abstract

Novel, potent farnesoid X receptor (FXR) and Peroxisome Proliferator-activated Receptor alpha (PPARalpha) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.