Azadideoxyadenosine: synthesis, enzymology, and anti-HIV activity

  • Bioorg Med Chem Lett. 2006 Aug 1;16(15):4099-101. doi: 10.1016/j.bmcl.2006.04.085.
Abdumalik A Nishonov  1 ,  Xiaohui Ma ,  Vasu Nair
Affiliations
  • 1. The Center for Drug Discovery and Department of Pharmaceutical and Biomedical Sciences, The University of Georgia, Athens, GA 30602, USA.
PMID: 16698265 DOI: 10.1016/j.bmcl.2006.04.085
Abstract

Synthesis of an azanucleoside, a new analogue of dideoxyadenosine, is described. This compound is only slowly deaminated by mammalian Adenosine Deaminase and it is a substrate for Adenosine Kinase. It exhibits in vitro anti-HIV activity.