Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis

  • Planta Med. 2006 Jul;72(9):847-50. doi: 10.1055/s-2006-931606.
Enos Tangke Arung  1 ,  Kuniyoshi Shimizu ,  Ryuichiro Kondo
Affiliations
  • 1. Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
PMID: 16732541 DOI: 10.1055/s-2006-931606
Abstract

Isoprenoid-substituted Flavonoids were isolated from the wood of Artocarpus heterophyllus by means of activity-guided fractionation. Artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5) and albanin A (6) inhibited melanin biosynthesis in B16 melanoma cells without inhibiting Tyrosinase. A structure-activity investigation indicated that the presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells.

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