N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor

  • Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. doi: 10.1016/j.bmcl.2006.05.051.
M Jonathan Fray  1 ,  Gerwyn Bish ,  Alan D Brown ,  Paul V Fish ,  Alan Stobie ,  Florian Wakenhut ,  Gavin A Whitlock
Affiliations
  • 1. Sandwich Chemistry, Pfizer Global Research and Development, Sandwich, UK. [email protected]
PMID: 16750359 DOI: 10.1016/j.bmcl.2006.05.051
Abstract

The synthesis and structure-activity relationships of a novel series of piperazine derivatives as dual inhibitors of serotonin and noradrenaline reuptake is described. Two compounds possessed comparable in vitro profiles to the dual reuptake inhibitor duloxetine.