Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists

  • J Med Chem. 2006 Jul 27;49(15):4781-4. doi: 10.1021/jm060389m.
Jin Hee Ahn  1 ,  Mi Sik Shin ,  Sun Ho Jung ,  Seung Kyu Kang ,  Kwang Rok Kim ,  Sang Dal Rhee ,  Won Hoon Jung ,  Sung Don Yang ,  Seung Jun Kim ,  Joo Rang Woo ,  Jeong Hyung Lee ,  Hyae Gyeong Cheon ,  Sung Soo Kim
Affiliations
  • 1. Bioorganic Science Division, Korea Research Institute of Chemical Technology, Yuseong-Gu, Daejeon, 305-600, Republic of Korea.
PMID: 16854085 DOI: 10.1021/jm060389m
Abstract

Agonists of Peroxisome Proliferator-activated Receptor gamma (PPAR gamma) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR gamma agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure.