Conjugated indole-imidazole derivatives displaying cytotoxicity against multidrug resistant cancer cell lines

  • Bioorg Med Chem Lett. 2006 Oct 1;16(19):5164-8. doi: 10.1016/j.bmcl.2006.07.020.
David A James  1 ,  Keizo Koya ,  Hao Li ,  Shoujun Chen ,  Zhiqiang Xia ,  Weiwen Ying ,  Yaming Wu ,  Lijun Sun
Affiliations
  • 1. Synta Pharmaceuticals, 45 Hartwell Ave, Lexington, MA 02421, USA.
PMID: 16870446 DOI: 10.1016/j.bmcl.2006.07.020
Abstract

We report herein the SAR studies of a series of indole-imidazole compounds. that demonstrate substantial in vitro anti-proliferative activities against Cancer cell lines, including multidrug resistance (MDR) phenotypes. The in vitro cytotoxic effects have been demonstrated across a wide array of tumor types, including hematologic and solid tumor cell lines of various origins (e.g., leukemia, breast, colon, and uterine).