Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains

  • Bioorg Med Chem Lett. 2006 Oct 15;16(20):5384-8. doi: 10.1016/j.bmcl.2006.07.060.
Sandra Gemma  1 ,  Gagan Kukreja ,  Caterina Fattorusso ,  Marco Persico ,  Maria P Romano ,  Maria Altarelli ,  Luisa Savini ,  Giuseppe Campiani ,  Ernesto Fattorusso ,  Nicoletta Basilico ,  Donatella Taramelli ,  Vanessa Yardley ,  Stefania Butini
Affiliations
  • 1. Dipartimento Farmaco Chimico Tecnologico, Università di Siena, via Aldo Moro, 53100 Siena, Italy.
PMID: 16890433 DOI: 10.1016/j.bmcl.2006.07.060
Abstract

A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs.