Cytotoxic cycloartane triterpene saponins from Actaea asiatica

  • J Nat Prod. 2006 Oct;69(10):1500-2. doi: 10.1021/np060113h.
Jingchun Gao  1 ,  Feng Huang ,  Jinchao Zhang ,  Guoyuan Zhu ,  Mengsu Yang ,  Peigen Xiao
Affiliations
  • 1. Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100094, People's Republic of China.
PMID: 17067171 DOI: 10.1021/np060113h
Abstract

Three new 9,19-cycloartane triterpene glycosides, asiaticoside A (1), asiaticoside B (2), and 25-O-ethylcimigenol-3-O-beta-D-xylopyranoside (3), together with cimiacemoside I (4), 25-O-acetylcimigenol-3-beta-O-D-xyloside (5), and 25-anhydrocimigenol-beta-O-D-xyloside (6) were isolated from the roots/rhizomes extract of Actaea asiatica, and their structures were established by spectroscopic methods (IR, HRESIMS, and NMR). Compounds 1-3, 5, and 6 had notable cytotoxicity against HepG2 and MCF-7 Cancer cell lines.

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