Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I

  • Bioorg Med Chem Lett. 2007 Apr 15;17(8):2312-6. doi: 10.1016/j.bmcl.2007.01.060.
Pratik V Devasthale  1 ,  Sean Chen ,  Yoon Jeon ,  Fucheng Qu ,  Denis E Ryono ,  Wei Wang ,  Hao Zhang ,  Lin Cheng ,  Dennis Farrelly ,  Rajasree Golla ,  Gary Grover ,  Zhengping Ma ,  Lisa Moore ,  Ramakrishna Seethala ,  Wei Sun ,  Arthur M Doweyko ,  Gamini Chandrasena ,  Paul Sleph ,  Narayanan Hariharan ,  Peter T W Cheng
Affiliations
  • 1. Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, USA. [email protected]
PMID: 17292606 DOI: 10.1016/j.bmcl.2007.01.060
Abstract

A novel series of potent dual agonists of PPARalpha and PPARgamma, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure-activity relationships of this series of dual PPARalpha/gamma agonists are described.