Chemotherapy of leishmaniasis. Part V: Synthesis and in vitro bioevaluation of novel pyridinone derivatives

  • Eur J Med Chem. 2007 May;42(5):669-74. doi: 10.1016/j.ejmech.2006.11.011.
Susmita Pandey  1 ,  S N Suryawanshi ,  Nishi ,  Neena Goyal ,  Suman Gupta
Affiliations
  • 1. Division of Medicinal Chemistry, Central Drug Research Institute, Chatter Manzil, Lucknow 226001, Uttar Pradesh, India.
PMID: 17306422 DOI: 10.1016/j.ejmech.2006.11.011
Abstract

Some novel 2-substituted pyridinone derivatives exemplified by 3 and 4 have been synthesized from 2-methyl-gamma-pyrone and screened towards in vitro antileishmanial activity profile. Some of the compounds such as 3a, 3b, 4i and 4j displayed good antileishmanial profile.