Synthesis and antibacterial activity of levofloxacin derivatives with certain bulky residues on piperazine ring

  • Eur J Med Chem. 2007 Jul;42(7):985-92. doi: 10.1016/j.ejmech.2006.12.034.
Alireza Foroumadi  1 ,  Saeed Emami ,  Shahla Mansouri ,  Azita Javidnia ,  Nosratollah Saeid-Adeli ,  Farshad H Shirazi ,  Abbas Shafiee
Affiliations
  • 1. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran.
PMID: 17316916 DOI: 10.1016/j.ejmech.2006.12.034
Abstract

A number of levofloxacin analogues carrying a 2-aryl-2-oxoethyl or a 2-aryl-2-oxyiminoethyl moiety attached to the piperazine ring at C-10 position have been prepared and evaluated as Antibacterial agents against a series of Gram-positive and Gram-negative bacteria. Some of them exhibited significant inhibitory activity against Gram-positive bacteria.