(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors

  • J Med Chem. 2007 Apr 5;50(7):1675-84. doi: 10.1021/jm0610292.
Kyeong Lee  1 ,  Jeong Hyung Lee ,  Shanthaveerappa K Boovanahalli ,  Yinglan Jin ,  Mijeoung Lee ,  Xuejun Jin ,  Jin Hwan Kim ,  Young-Soo Hong ,  Jung Joon Lee
Affiliations
  • 1. Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, 305-806.
PMID: 17328532 DOI: 10.1021/jm0610292
Abstract

Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1alpha protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.