Habbemines A and B, pyrrolidine alkaloids with human delta-opioid receptor binding affinity from the leaves of Elaeocarpus habbemensis

  • J Nat Prod. 2007 May;70(5):866-8. doi: 10.1021/np060577f.
Peter L Katavic  1 ,  Debra A Venables ,  Topul Rali ,  Anthony R Carroll
Affiliations
  • 1. Natural Product Discovery, Eskitis Institute, Griffith University, Brisbane, Queensland, Australia .
PMID: 17388627 DOI: 10.1021/np060577f
Abstract

The first phytochemical investigation of the Papua New Guinean plant Elaeocarpus habbemensis resulted in the isolation of two new pyrrolidine Alkaloids, habbemines A (2) and B (3), as a 1:1 mixture of inseparable diastereomers. The structures of these compounds and their relative configurations were determined by spectroscopic means. An equimolar mixture of habbemines A and B showed human delta-opioid receptor binding affinity with an IC50 of 32.1 microM.