Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera

  • Arch Pharm Res. 2007 Mar;30(3):299-302. doi: 10.1007/BF02977609.
Mi Kyeong Moon  1 ,  Hyun Mi Oh ,  Byoung-Mog Kwon ,  Nam-In Baek ,  Sung-Hoon Kim ,  Ju Sin Kim ,  Dae Keun Kim
Affiliations
  • 1. College of Pharmacy, Woosuk University, Samrye 565-701, Korea.
PMID: 17424934 DOI: 10.1007/BF02977609
Abstract

The methanolic extract of the leaves of Liriodendron tulipifera was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of lipiferolide, an inhibitor of FPTase. This compound inhibited the FPTase activity in a dose-dependent manner, and showed cell growth inhibitory activity against several tumor cells.

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