Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs

  • Bioorg Med Chem. 2007 Jun 15;15(12):4016-37. doi: 10.1016/j.bmc.2007.03.086.
Anders Vik  1 ,  Erik Hedner ,  Colin Charnock ,  Linda W Tangen ,  Ørjan Samuelsen ,  Rolf Larsson ,  Lars Bohlin ,  Lise-Lotte Gundersen
Affiliations
  • 1. Department of Chemistry, University of Oslo, Blindern, N-0315 Oslo, Norway.
PMID: 17442577 DOI: 10.1016/j.bmc.2007.03.086
Abstract

Agelasine and agelasimine derivatives with substantially less complicated terpenoid side chains compared to the naturally occurring compounds have been synthesized and their ability to inhibit growth of Microorganisms and Cancer cells has been studied. Compounds with excellent activity against Cancer cell lines (MIC CA. 1 microM for the most potent compounds), including a drug resistant renal cell line, have been identified. Most compounds studied also exhibited broad spectrum antimicrobial activity including activity against Mycobacterium tuberculosis.