Triterpenoids from Schisandra rubriflora

  • J Nat Prod. 2007 Jun;70(6):1056-9. doi: 10.1021/np0700927.
Wei-Lie Xiao  1 ,  Xiao-Li Li ,  Rui-Rui Wang ,  Liu-Meng Yang ,  Li-Mei Li ,  Sheng-Xiong Huang ,  Jian-Xin Pu ,  Yong-Tang Zheng ,  Rong-Tao Li ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
PMID: 17489633 DOI: 10.1021/np0700927
Abstract

Investigation of an organic extract of Schisandra rubriflora led to the isolation of three new highly oxygenated nortriterpenoids, named rubriflorins A-C (1-3), together with six related known compounds (4-9). Their structures were elucidated by spectroscopic evidence. Compounds 1-3 feature the opening of ring A compared with related known nortriterpenoids isolated from the genus Schisandra and showed anti-HIV-1 activities with EC50 values of 10.0, 16.2, and 81.3 microg/mL, respectively.