The discovery of long acting beta2-adrenoreceptor agonists

  • Bioorg Med Chem Lett. 2007 Jul 15;17(14):4012-5. doi: 10.1016/j.bmcl.2007.04.081.
Alan D Brown  1 ,  Mark E Bunnage ,  Paul A Glossop ,  Kim James ,  Rhys Jones ,  Charlotte A L Lane ,  Russell A Lewthwaite ,  Simon Mantell ,  Christelle Perros-Huguet ,  David A Price ,  Mike Trevethick ,  Rob Webster
Affiliations
  • 1. Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.
PMID: 17498952 DOI: 10.1016/j.bmcl.2007.04.081
Abstract

The design and profile of a series of saligenin containing long acting beta(2)-adrenoreceptor agonists is described. Evaluation of these analogues using a guinea-pig tissue model demonstrates that analogues within this series have significantly longer durations of action than salmeterol and have the potential for a once daily profile in human.