Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol

  • Bioorg Med Chem Lett. 2007 Aug 15;17(16):4428-31. doi: 10.1016/j.bmcl.2007.06.024.
Franck Amblard  1 ,  Baskaran Govindarajan ,  Benjamin Lefkove ,  Kimberly L Rapp ,  Mervi Detorio ,  Jack L Arbiser ,  Raymond F Schinazi
Affiliations
  • 1. Department of Pediatrics and Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA.
PMID: 17587572 DOI: 10.1016/j.bmcl.2007.06.024
Abstract

A series of new bisphenol derivatives bearing allylic moieties were synthesized as potential analogs of honokiol and/or magnolol. Certain compounds exhibited specific anti-proliferation activity against SVR cells and moderate anti-HIV-1 activity in primary human lymphocytes. Compound 5h was the most potent compound and its anti-tumor activity was evaluated in vivo.