Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents

  • Bioorg Med Chem. 2007 Sep 15;15(18):6018-26. doi: 10.1016/j.bmc.2007.06.047.
D L A Rakotondramanana  1 ,  Mélanie Delomenède ,  Michel Baltas ,  Hubert Duran ,  Florence Bedos-Belval ,  Philippe Rasoanaivo ,  Anne Negre-Salvayre ,  Heinz Gornitzka
Affiliations
  • 1. Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique, LSPCMIB, UMR-CNRS 5068, Université Paul Sabatier, 118, Route de Narbonne, 31062 Toulouse Cedex 9, France.
PMID: 17624792 DOI: 10.1016/j.bmc.2007.06.047
Abstract

Oxidative dimerization of ferulic acid methyl ester afforded dihydrobenzofuran derivative and new linear compound identified by X-ray crystallography. The gallate derivatized dihydrobenzofuran analogue was obtained and all compounds were evaluated for potential antiatherogenic, antiplasmodial (best IC(50)=0.8 microM) and cytotoxic activities.