Insight into the reactive form of the anticancer agent iproplatin

  • Eur J Med Chem. 2008 May;43(5):1081-4. doi: 10.1016/j.ejmech.2007.06.019.
Erika Volckova  1 ,  Evelyne Weaver ,  Rathindra N Bose
Affiliations
  • 1. Michael Faraday Laboratory, Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL 60115, United States.
PMID: 17707553 DOI: 10.1016/j.ejmech.2007.06.019
Abstract

The reaction of iproplatin with reduced glutathione at different mole ratios yielded cis-di(isopropylamine)chloro-glutathionatoplatinum(II), not the expected cis-dichloro- species, indicating a mode of action of this Anticancer agent that is different from that of cis-diamminedichloroplatinum(II).

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