Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator

  • Bioorg Med Chem Lett. 2007 Nov 15;17(22):6274-9. doi: 10.1016/j.bmcl.2007.09.012.
George P Lahm  1 ,  Thomas M Stevenson ,  Thomas P Selby ,  John H Freudenberger ,  Daniel Cordova ,  Lindsey Flexner ,  Cheryl A Bellin ,  Christine M Dubas ,  Ben K Smith ,  Kenneth A Hughes ,  J Gary Hollingshaus ,  Christopher E Clark ,  Eric A Benner
Affiliations
  • 1. DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA. [email protected]
PMID: 17884492 DOI: 10.1016/j.bmcl.2007.09.012
Abstract

Rynaxypyr is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over mammalian receptors. The synthesis and biological results are presented.