Biotransformation of adrenosterone by filamentous fungus, Cunninghamella elegans

  • Steroids. 2007 Dec;72(14):923-9. doi: 10.1016/j.steroids.2007.08.002.
Muhammad Iqbal Choudhary  1 ,  Naik T Khan ,  Syed G Musharraf ,  Shazia Anjum ,  Atta-Ur-Rahman
Affiliations
  • 1. HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan. [email protected]
PMID: 17889091 DOI: 10.1016/j.steroids.2007.08.002
Abstract

Microbial transformation of adrenosterone (1) by suspended-cell cultures of the filamentous fungus Cunninghamella elegans resulted in the production of five metabolites 2-6, which were identified as 9alpha-hydroxyadrenosterone (2), 11-ketotestosterone (3), 6beta-hydroxyadrenosterone (4), 9alpha-hydroxy-11-ketotestosterone (5), and 6beta-hydroxy-11-ketotestosterone (6). Structures of new metabolites 2, 5, and 6 were established by single-crystal X-ray diffraction analysis.

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