The discovery of indole-derived long acting beta2-adrenoceptor agonists for the treatment of asthma and COPD

  • Bioorg Med Chem Lett. 2007 Nov 15;17(22):6188-91. doi: 10.1016/j.bmcl.2007.09.031.
Alan D Brown  1 ,  Mark E Bunnage ,  Paul A Glossop ,  Mark Holbrook ,  Rhys D Jones ,  Charlotte A L Lane ,  Russell A Lewthwaite ,  Simon Mantell ,  Christelle Perros-Huguet ,  David A Price ,  Rob Webster
Affiliations
  • 1. Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent, UK.
PMID: 17897826 DOI: 10.1016/j.bmcl.2007.09.031
Abstract

The design and profile of a series of indole containing long acting beta(2)-adrenoceptor agonists is described. Evaluation of these analogues using an in vitro guinea pig trachea tissue model demonstrates that analogues within this series have salmeterol-like duration of action with potential for long duration of action in humans.