Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents

  • Bioorg Med Chem Lett. 2007 Dec 15;17(24):6895-8. doi: 10.1016/j.bmcl.2007.09.096.
Maria Cristina Silva Lourenço  1 ,  Felipe Rodrigues Vicente ,  Maria das Graças Muller de Oliveira Henriques ,  André Luis Peixoto Candéa ,  Raoni Schroeder Borges Gonçalves ,  Thais Cristina M Nogueira ,  Marcelle de Lima Ferreira ,  Marcus Vinícius Nora de Souza
Affiliations
  • 1. Instituto de Pesquisas Clínica Evandro Chagas-IPEC, Av. Brasil, 4365 Manguinhos Rio de Janeiro, RJ, Brazil.
PMID: 17967538 DOI: 10.1016/j.bmcl.2007.09.096
Abstract

The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro Antibacterial activity against Mycobacterium Tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mug/mL. The compounds 2, 3, 7, 8, 11, 12, 15, 16, and 20 exhibited activity between 25 and 100 microg/mL and could be a good start point to find new lead compounds in the fight against multidrug resistant Tuberculosis.

Products