Inhibition of inducible prostaglandin E2 production and cyclooxygenase-2 expression by curdione from Curcuma zedoaria

  • Arch Pharm Res. 2007 Oct;30(10):1236-9. doi: 10.1007/BF02980264.
O-Jin Oh  1 ,  Hye-Young Min ,  Sang Kook Lee
Affiliations
  • 1. College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
PMID: 18038902 DOI: 10.1007/BF02980264
Abstract

Overproduction of prostaglandins has been considered in mediation of inflammation and carcinogenic process. On this line, the inhibitors of prostaglandin biosynthetic enzyme cyclooxygenase (COX) have played a role of anti-inflammatory and Cancer chemopreventive agents. In our continuous efforts to search anti-inflammatory and chemopreventive agents from natural products, bioassay-guided fractionation led to the isolation of curdione from the rhizome of Curcuma zedoaria with the inhibitory effect on the production of prostaglandin E2 in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells in a concentration-dependent manner (IC50 = 1.1 microM). Mechanistic studies suggest that the suppression of cyclooxygenase-2 (COX-2) mRNA expression is, at least in part, involved in this inhibitory activity of curdione.

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