Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia(1)

  • J Nat Prod. 2007 Dec;70(12):2045-8. doi: 10.1021/np0704553.
Ya-Ming Xu  1 ,  Steven P McLaughlin ,  A A Leslie Gunatilaka
Affiliations
  • 1. SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, Tucson, AZ 85706-6800, USA.
PMID: 18052324 DOI: 10.1021/np0704553
Abstract

Four new diene valepotriates, sorbifolivaltrates A-D ( 1- 4), and the known compounds isovaltrate ( 5), valtrate ( 6), seneciovaltrate ( 7), valtrate hydrine B3 ( 8), and valtrate hydrine B7 ( 9), have been isolated by bioassay-guided fractionation of the cytotoxic hexanes and methyl ethyl ketone crude extracts of the aerial parts of Valeriana sorbifolia occurring in the Sonoran desert. The structures of 1- 4 were determined on the basis of their high-resolution mass spectrometric and NMR spectroscopic data. All compounds exhibited weak to moderate cytotoxicity against the human metastatic prostate Cancer cell line, PC-3M.