Cytotoxic diterpenoids and sesquiterpenoids from Pteris multifida

  • J Nat Prod. 2008 Feb;71(2):227-31. doi: 10.1021/np0706421.
Xin Ge  1 ,  Guan Ye ,  Ping Li ,  Wen-Jie Tang ,  Jin-Li Gao ,  Wei-Min Zhao
Affiliations
  • 1. Central Research Institute of Shanghai Pharmaceutical Group, Shanghai 201203, People's Republic of China.
PMID: 18181575 DOI: 10.1021/np0706421
Abstract

Three new ent-kaurane Diterpenoids, named pterokaurane M 1-M 3 ( 1- 3) and three new C 14 pterosin-sesquiterpenoids, named multifidoside A-C ( 4- 6), along with 18 known compounds, were isolated from the whole Plants of Pteris multifida . The structures of 1- 6 were established using spectroscopic methods, including extensive 2D NMR and CD analyses. Compounds 4 and 5 showed cytotoxicity against the HepG2 tumor cell line with IC 50 values of less than 10 microM.