Tasumatrols U-Z, taxane diterpene esters from Taxus sumatrana

  • J Nat Prod. 2008 Apr;71(4):576-80. doi: 10.1021/np078016r.
Ya-Ching Shen  1 ,  Shih-Sheng Wang ,  Ching-Te Chien ,  Yao-Haur Kuo ,  Ashraf Taha Khalil
Affiliations
  • 1. School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd. Sec. 1, Taipei 100, Taiwan. [email protected]
PMID: 18220355 DOI: 10.1021/np078016r
Abstract

Phytochemical investigation of the leaves and twigs of Taxus sumatrana afforded six new taxane diterpene esters, tasumatrols U-Z ( 1- 6). Compounds 2 and 5 contained a rare five-membered lactone ring at C-8, C-9, C-10, and C-19. The structures were established on the basis of detailed spectroscopic analyses, particularly HRESIMS and 2D NMR techniques. Compound 5 showed cytotoxicity against a human hepatoma (Hep2) cell line.