Discovery of novel FMS kinase inhibitors as anti-inflammatory agents

  • Bioorg Med Chem Lett. 2008 Mar 1;18(5):1642-8. doi: 10.1016/j.bmcl.2008.01.059.
Carl R Illig  1 ,  Jinsheng Chen ,  Mark J Wall ,  Kenneth J Wilson ,  Shelley K Ballentine ,  M Jonathan Rudolph ,  Renee L DesJarlais ,  Yanmin Chen ,  Carsten Schubert ,  Ioanna Petrounia ,  Carl S Crysler ,  Christopher J Molloy ,  Margery A Chaikin ,  Carl L Manthey ,  Mark R Player ,  Bruce E Tomczuk ,  Sanath K Meegalla
Affiliations
  • 1. Johnson & Johnson Pharmaceutical Research & Development, Welsh & McKean Roads, Spring House, PA 19477, USA.
PMID: 18242992 DOI: 10.1016/j.bmcl.2008.01.059
Abstract

The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC(50)=0.0008 microM) served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice.

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