Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds

  • Bioorg Med Chem. 2008 Apr 15;16(8):4733-41. doi: 10.1016/j.bmc.2008.02.026.
Cyrille Tomassi  1 ,  Albert Nguyen Van Nhien ,  José Marco-Contelles ,  Jan Balzarini ,  Christophe Pannecouque ,  Erik De Clercq ,  Denis Postel
Affiliations
  • 1. Laboratoire des Glucides (UMR6219), Faculté des Sciences, Université de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens, France.
PMID: 18316194 DOI: 10.1016/j.bmc.2008.02.026
Abstract

Aza TSAO-T derivatives bearing a substituted dihydroisothiazole dioxide ring with a phenyl group at 5'' position were prepared. Biological evaluation showed that phenyl group gives rise to a dramatical decrease of the inhibitory effect.