Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound

  • Bioorg Med Chem Lett. 2008 Apr 1;18(7):2277-81. doi: 10.1016/j.bmcl.2008.03.010.
Cyrille Tomassi  1 ,  Van Nhien Albert Nguyen ,  José Marco-Contelles ,  Jan Balzarini ,  Christophe Pannecouque ,  Erik De Clercq ,  Elena Soriano ,  Denis Postel
Affiliations
  • 1. Laboratoire des Glucides (UMR6219), Université de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens, France.
PMID: 18353641 DOI: 10.1016/j.bmcl.2008.03.010
Abstract

The synthesis and the biological evaluation of the anti-HIV-1 activity of TSAO-Boc(3)T (8) are described. The computational analysis showed that the N-3 Boc group promotes new interactions in the binding site of the enzyme leading to a good inhibitory activity.