In vivo anti-inflammatory effect of a new steroidal saponin, mannioside A, and its derivatives isolated from Dracaena mannii

  • Arch Pharm Res. 2008 May;31(5):653-8. doi: 10.1007/s12272-001-1208-3.
Leon Azefack Tapondjou  1 ,  Kemvoufo Beaudelaire Ponou ,  Remy Bertrand Teponno ,  Marius Mbiantcha ,  Jules Désiré Djoukeng ,  Télesphore Benoit Nguelefack ,  Pierre Watcho ,  Aurelio Gomez Cadenas ,  Hee-Juhn Park
Affiliations
  • 1. Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
PMID: 18481024 DOI: 10.1007/s12272-001-1208-3
Abstract

A new steroidal saponin, mannioside A (1), was isolated from the stem bark of Dracaena mannii, together with the known pennogenin (2), pennogenin-3-O-beta-D-glucopyranoside (3) and pennogenin-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->3)]-beta-D-glucopyranoside (4). Their structures were determined using 1D-and 2D-NMR spectroscopy and mass spectrometry. Compounds 1 and 3 significantly inhibited carrageenan-induced paw edema in the rat; compound 4 was moderately active whereas 2 showed very weak activity.

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